6-Fluoro-3-Hydroxypyrazine-2-Carbonitrile CAS 356783-31-8 Purity ≥98.0% (HPLC) Favipiravir Intermediate COVID-19

6-Fluoro-3-Hydroxypyrazine-2-Carbonitrile (CAS 356783-31-8) is an Intermediate of Favipiravir (CAS 259793-96-9). Favipiravir is a new broad-spectrum antiviral drug targeting RNA-dependent RNA polymerase (RdRp). Favipiravir was originally developed in the late 1990s by a company that was later purchased by the Japanese firm Fujifilm as part of its transition from the photo business to healthcare. After being tested against a range of viruses, the drug was approved in Japan in 2014 for emergency use against flu epidemics or to treat new strains of influenza. During the outbreak of the new coronavirus, the results of the Phase I clinical study of the drug published in March 2020 showed that the drug may have the effect of speeding up virus clearance to alleviate the progress of new coronavirus pneumonia. Favipiravir can be used in the treatment of patients with COVID-19 recommended by WHO. It was cleared by the Drugs Controller General of India (DCGI) for “emergency restricted” use among COVID-19 patients.